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San Luis, officially the Municipality of San Luis (Cebuano: Lungsod sa San Luis; Filipino: Bayan ng San Luis), is a municipality in the province of Agusan del Sur in the Caraga (Region XIII) of the Philippines. The population was 32,109 at the 2015 census.[3] In the 2016 electoral roll, it had 16,701 registered voters.[4]

San Luis was created into a municipality on June 15, 1968, when the barrios of San Luis, Santa Inez, Nuevo Trabajo, Cualision and Baylo were separated from the municipality of Esperanza and constituted into the new town, through Republic Act 5262.[5] Since the 1970s, the town's economy has been largely based on logging industries.